甘肃产蓝萼香茶菜二萜化学成分研究

丁 兰<sup>1</sup>; 王 炜<sup>1</sup>; 汪 涛<sup>2</sup>; 王 丽<sup>1</sup>; 汪汉卿<sup>3</sup>

引用本文:	丁兰, 王炜, 汪涛, 王丽, 汪汉卿.甘肃产蓝萼香茶菜二萜化学成分研究[J].广西植物,2008,(2):265-268.[点击复制]
	DING Lan, WANG Wei, WANG Tao, WANG Li, WANG Han-Qing.Chemical components of diterpenoids from Isodon japonica var.galaucocalyx from Gansu Province, China[J].Guihaia,2008,(2):265-268.[点击复制]

【打印本页】【下载PDF全文】【查看/发表评论】【下载PDF阅读器】【关闭】

←前一篇|后一篇→

过刊浏览高级检索

本文已被：浏览 5908次下载 2344次	码上扫一扫！
分享到：微信更多字体:加大+\|默认\|缩小-
甘肃产蓝萼香茶菜二萜化学成分研究
丁兰¹, 王炜¹, 汪涛², 王丽¹, 汪汉卿³
1.西北师范大学生命科学学院, 兰州 730070;2.菏泽学院化学化工系, 山东菏泽 274015;3.中国科学院兰州化学物理研究所 OSSO国家重点实验室, 兰州 730000

摘要:

对甘肃天水小陇山产蓝萼香茶菜进行二萜化学成分研究。采用硅胶柱色谱法分离纯化,通过薄层色谱及波谱法进行结构鉴定,SRB法分别对分离化合物进行了体外细胞毒活性测试。共鉴定出5个二萜化合物,它们分别为:1α,6,11β,15β-四乙酰基-6,7-断裂-7,20-内酯-对映-贝壳杉-16-烯(1α,6,11β,15β-tetraacetoy-6,7-seco-7,20-olide-ent-kaur-16-en,Ⅰ),6β,11α-二羟基-6,7-断裂-6,20-环氧-1α,7-内酯-对映-贝壳杉-16-烯-15-酮(6β,11α-dihydroxy-6,7-seco-6,20-epoxy-1α,7-olide-ent-kaur-16-en-15-one,Ⅱ),6β,7β,14β-三羟基-1α-乙酰氧基-7α,20-环氧-对映-贝壳杉-16烯-15-酮(6β,7β,14β-trihydroxy-1α-acetoxy-7α,20-epoxy-ent-kaur-16-en-15-one,Ⅲ),6β,11α,15α-三羟基-6,7-断裂-6,20-环氧-1α,7-内酯-对映-贝壳杉-16-烯(6β,11α,15α-trihydroxy-6,7-seco-6,20-epoxy-1α,7-olide-ent-kaur-16-en,Ⅳ),1α,6β,7β,14β-四羟基-7α,20-环氧-对映-贝壳杉-16-烯-15-酮(1α,6β,7β,14β-tetrahydroxy-7α-20-epoxy-ent-kaur-16-en-15-one,Ⅴ)。化合物Ⅲ、Ⅳ、Ⅴ均为首次从该植物中分离得到,并且以上5个二萜化合物对人肝癌细胞株Bel-7402和人卵巢癌细胞株HO-8910均显示了良好的细胞毒活性。

关键词: 蓝萼香茶菜二萜结构鉴定细胞毒活性

DOI：

分类号:Q946

基金项目:

Chemical components of diterpenoids from Isodon japonica var.galaucocalyx from Gansu Province, China

DING Lan¹, WANG Wei¹, WANG Tao², WANG Li¹, WANG Han-Qing³

1.College of Life Sciences, Northwest Normal University, Lanzhou 730070, China;2.Department of Chemistry and Chemical Engineering, Heze University, Heze 274015, China;3.State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, The Chinese Academy of Sciences, Lanzhou 730000, China 1.College of Life Sciences, Northwest Normal University, Lanzhou 730070, China; 2.Department of Chemistry and Chemical Engineering, Heze University, Heze 274015, China; 3.State Key Laboratory for Oxo Synthesis and Selective Oxidation, Lanzhou Institute of Chemical Physics, The Chinese Academy of Sciences, Lanzhou 730000, China

Abstract:

Chemical constituents of diterpenoids from Isodon japonica var.galaucocalyx were studied. The compounds were isolated by column Chromatography and the structures of these compounds were elucidated by means of spectral analysis. The antitumor activity was determined in vitro by the SRB assay. Five compounds were isolated and identified as Rabdesinate(Ⅰ),Epinodosin(Ⅱ),Lasiokaourin(Ⅲ),Epinodosinol(Ⅳ)and Oridonin(Ⅴ),respectively. These compounds have significant cytotoxicity against Bel-7402 and HO-8910. Compounds Ⅲ,Ⅳ,Ⅴ of them were obtained form I.japonica var.galaucocalyx for the first time.

Key words: Isodon japonica var.galaucocalyx diterpenoids structural identification cytotoxicity