光叶兔儿风的化学成分研究

陈亚萍<sup>1; 2</sup>; 王书林<sup>1</sup>; 沈云亨<sup>2</sup>; 吴志军<sup>3*</sup>

引用本文:	陈亚萍, 王书林, 沈云亨, 吴志军.光叶兔儿风的化学成分研究[J].广西植物,2014,(3):402-407.[点击复制]
	CHEN Ya-Ping, WANG Shu-Lin, SHEN Yun-Heng, WU Zhi-Jun.Chemical constituents from Ainsliaea glabra[J].Guihaia,2014,(3):402-407.[点击复制]

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光叶兔儿风的化学成分研究
陈亚萍^1,2, 王书林¹, 沈云亨², 吴志军^3*
1. 成都中医药大学, 成都 611137;2. 第二军医大学药学院天然药化教研室, 上海 200003;3. 第二军医大学附属长征医院药学部, 上海 200433

摘要:

利用正反相硅胶、凝胶(Sephadex LH-20)等多种柱色谱法,对光叶兔儿风化学成分进行分离纯化,并根据理化性质和波谱数据进行结构鉴定。结果表明:已分离得到17个化合物,分别鉴定为蒲公英甾醇乙酸酯(1),三十二碳烯(2),β-谷甾醇(3),大黄酚(4),扇醇棕榈酸酯(5),亚麻酸甲酯(6),亚油酸(7),植物醇(8),[24S]-豆甾-4烯-3-酮(9),植物烯醛(10),白桦脂酸(11),13-羰基-十八碳二烯酸(12),E-7,9-11-羰基-棕榈酸(13),蒲公英酸(14),3β-羟基-胆甾-5-烯(15),环氧树脂烯(16),28-O-月桂酸酯白桦醇(17)。化合物1～17均为首次从该植物中分离得到。

关键词: 光叶兔儿风化学成分结构鉴定

DOI：10.3969/j.issn.1000-3142.2014.03.022

分类号:Q946.91

基金项目:

Chemical constituents from Ainsliaea glabra

CHEN Ya-Ping^1,2, WANG Shu-Lin¹, SHEN Yun-Heng², WU Zhi-Jun^3*

1. Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China;2. Department of Phytochemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China;3. Department of Pharmacology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China 1. Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China; 2. Department of Phytochemistry, School of Pharmacy, Second Military Medical University, Shanghai 200433, China; 3. Department of Pharmacology, Changzheng Hospital, Second Military Medical University, Shanghai 200003, China

Abstract:

To investigate the chemical constituents of Ainsliaea glabra,several chromatographies including Silica gel column chromatography and Sephadex LH-20 gel column chromatography were applied to the isolation and purification of chemical constituents. The structures were identified on the basis of chemical evidence and spectral data.The results showed that seventeen compounds were isolated from A. glabra and they were identified as taraxasteryl acetate(1),dotriacont-1-ene(2),β-sitosterol(3),chrysophanol(4),lupenyl palmitate(5),methyl linolenate(6),linoleic acid(7),phytol(8),stigmast-4-en-3-one(9),phytenal(10),betulinic acid(11),(9Z,11E)-13-oxo-9,11-ocatadecadienoic acid(12),E-7,9-diene-11-methenyl palmitic acid(13),taraxinic acid(14),3β-hydroxy-cholesta-5-ene(15),epoxylycopaene(16),28-O-laurylbetulin(17). Compounds 1-17 were obtained from this herb for the first time.

Key words: Ainsliaea glabra chemical constituent structure identification