石山巴豆枝叶的化学成分研究

夏梦雯<sup>1; 2</sup>; 宁德生<sup>1</sup>; 黄思思<sup>1</sup>; 程 玲<sup>1; 2</sup>; 吕仕洪<sup>1</sup>; 罗 蕾<sup>2</sup>; 潘争红<sup>1*</sup>

引用本文:	夏梦雯, 宁德生, 黄思思, 程玲, 吕仕洪,罗蕾, 潘争红.石山巴豆枝叶的化学成分研究[J].广西植物,2016,36(10):1186-1191.[点击复制]
	XIA Meng-Wen, NING De-Sheng, HUANG Si-Si, CHENG Ling, LV Shi-Hong, LUO Lei, PAN Zheng-Hong.Chemical constituents from the branches and leaves of Croton euryphyllus[J].Guihaia,2016,36(10):1186-1191.[点击复制]

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石山巴豆枝叶的化学成分研究
夏梦雯^{1, 2}, 宁德生¹, 黄思思¹, 程玲^{1, 2}, 吕仕洪¹,罗蕾², 潘争红^1*
1. 广西植物功能物质研究与利用重点实验室, 广西壮族自治区中国科学院广西植物研究所, 广西桂林 541006;2. 云南师范大学化学化工学院, 昆明 650500

摘要:

石山巴豆(Croton euryphyllus)为大戟科(Euphorbiaceae)巴豆属(Croton)植物,主要分布于西南各省的岩溶石山地区,民间用于杀虫和治疗跌打损伤。为了阐明其化学物质基础,该研究采用硅胶柱层析、Sephadex LH-20、HPLC等方法对石山巴豆枝叶醇提物进行分离纯化。结果表明:共分离得到16个化合物,分别鉴定为异毛叶巴豆萜(1), jatrophoidin(2), 山藿香定(3), 异山藿香素(4), 山藿香素(5), 赖百当-13-烯-8,15-二醇(6), 7-酮基-β-谷甾醇(7),(22E)-5α,8β-表二氧麦角甾-6,22-二烯-3β-醇(8), 豆甾烷-4-烯-6β-醇-3-酮(9), 齐墩果烷-12-烯-2α,3β-二醇(10), 东莨菪内酯(11), 催吐萝芙木醇(12), lyratol F(13), 罗布麻酚A(14), 芹菜素(15), 金色酰胺醇酯(16)。所有化合物均为首次从该植物中分离得到,其中化合物8-16为首次从巴豆属中发现。

关键词: 石山巴豆, 化学成分, 二萜, 甾醇, 结构鉴定

DOI：10.11931/guihaia.gxzw201509026

分类号:

文章编号:1000-3142(2016)10-1186-06

基金项目:国家自然科学基金(21102023); 广西自然科学基金(2011GXNSFB018022); 中国科学院“西部之光”人才培养计划项目(2012)[Supported by the National Natural Science Foundation of China(21102023); the Natural Science Foundation of Guangxi(2011GXNSFB018022); the West Light Foundation of the Chinese Academy of Sciences(2012)]。

Chemical constituents from the branches and leaves of Croton euryphyllus

XIA Meng-Wen^1,2, NING De-Sheng¹, HUANG Si-Si¹, CHENG Ling^1,2, LV Shi-Hong¹, LUO Lei², PAN Zheng-Hong^1*

1. Guangxi Key Laboratory of Functional Phytochemicals Research and Utilization, Guangxi Institute of Botany, Chinese Academy of Sciences, Guilin 541006, Guangxi, China;2. Faculty of Chemistry and Chemical Engineering, Yunnan Normal University, Kunming 650500, China 1. Guangxi Key Laboratory of Functional Phytochemicals Research and Utilization, Guangxi Institute of Botany, Chinese Academy of Sciences, Guilin 541006, Guangxi, China; 2. Faculty of Chemistry and Chemical Engineering, Yunnan Normal University, Kunming 650500, China

Abstract:

Croton euryphyllus(Euphorbiaceae)is mainly distributed in the karst region of Southwest China and has been used as a folk medicine to cure traumatic injury and kill insects. In order to clarify the chemical constituents of C. euryphyllus, the ethanol extract was separated by the chromatography(silica gel, Sephadex LH-20 and HPLC)and sixteen compounds were isolated. Their structures were elucidated as: isocrotocaudin(1), jatrophoidin(2), teucvidin(3), isoteucvin(4), teucvin(5), labd-13E-ene-8β,15-diol(6), 7-oxo-β-sitosterol(7),(22E)-5α, 8β-epidioxyergosta-6, 22-dien-3β-ol(8), stigmast-4-en-6β-ol-3-one(9), olean-12-en-2α,3β-diol(10), scopoletin(11), vomifoliol(12), lyratol F(13), apocynol A(14), apigenin(15), aurantiamide acetate(16). All compounds were firstly isolated from this plant, and compounds 8-16 were isolated from the genus Croton for the first time.

Key words: Croton euryphyllus, chemical constituents, diterpenoid, sterol, structure identification