| 引用本文: | 吴 蕾, 李金杰, 钟祥健, 周 娜, 王 欣, 林鹏程.云南兔儿风的化学成分研究[J].广西植物,2020,40(9):1375-1380.[点击复制] |
| WU Lei, LI Jinjie, ZHONG Xiangjian, ZHOU Na, WANG Xin, LIN Pengcheng.Chemical constituents from Ainsliaea yunnanensis[J].Guihaia,2020,40(9):1375-1380.[点击复制] |
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| 云南兔儿风的化学成分研究 |
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吴 蕾1,2, 李金杰3, 钟祥健3, 周 娜3, 王 欣3, 林鹏程1,2*
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1. 青海民族大学 药学院, 西宁 810007;2. 青藏高原植物化学重点实验室, 西宁 810007;3. 北京联合大学 生物活性物质与功能食品北京市重点实验室, 北京 100191
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| 摘要: |
| 为研究我国特有植物云南兔儿风的化学成分,该文采用常压正相硅胶色谱、凝胶色谱、低压氰基液相色谱和反相高压液相色谱等方法,对其乙醇提取物进行分离纯化并进行结构鉴定。结果表明:首次从云南兔儿风中分离并鉴定了10个化合物,包括6个甾体类、3个苯丙酸类和1个酚酸类,分别为3β-羟基豆甾-5-烯-7-酮(1)、3β-羟基豆甾-5,22-二烯-7-酮(2)、β-谷甾醇(3)、豆甾醇(4)、β-胡萝卜苷(5)、豆甾醇-3-O-葡萄糖苷(6)、3,5-O-二咖啡酰奎尼酸(7)、3,5-O-二咖啡酰奎尼酸甲酯(8)、咖啡酸(9)、原儿茶酸(10)。其中,化合物2和8是在兔儿风属中首次发现,所有化合物都是从云南兔儿风中首次发现。以上化合物的发现丰富了云南兔儿风的化学成分,为其合理、有效的应用提供了理论依据。 |
| 关键词: 云南兔儿风, 分离纯化, 结构鉴定 |
| DOI：10.11931/guihaia.gxzw201910043 |
| 分类号:Q946.8 |
| 文章编号:1000-3142(2020)09-1375-06 |
| 基金项目:北京市教委科技计划重点项目(KZ201811417049); 北京市教委面上项目(KM201811417008, KM202011417014); 北京联合大学人才强校优选-百优计划项目(BPHR2019DZ03); 青海省青藏高原植物化学重点实验室专项(2017-ZJ-Y19)[Supported by the Key Projects of the Beijing Natural Sciences Foundation and Beijing Municipal Education Committee(KZ201811417049); Scientific Research Common Program of Beijing Municipal Commission of Education(KM201811417008, KM202011417014); Premium Funding Project for Academic Human Resources Development in Beijing Union University(BPHR2019DZ03); Special Project for Key Laboratory of Plant Resources of Qinghai-Tibet Plateau in Chemical Research(2017-ZJ-Y19)]。 |
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| Chemical constituents from Ainsliaea yunnanensis |
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WU Lei1,2, LI Jinjie3, ZHONG Xiangjian3, ZHOU Na3, WANG Xin3, LIN Pengcheng1,2*
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1. Department of Pharmacy, Qinghai University for Nationalities, Xining 810007, China;2. Key Laboratory of Plant Resources of
Qinghai-Tibet Planteau in Chemical Research, Xining 810007, China;3. Beijing Key Laboratory of Bioactive
Substance and Functional Foods, Beijing Union University, Beijing 100191, China
1. Department of Pharmacy, Qinghai University for Nationalities, Xining 810007, China; 2. Key Laboratory of Plant Resources of
Qinghai-Tibet Planteau in Chemical Research, Xining 810007, China; 3. Beijing Key Laboratory of Bioactive
Substance and Functional Foods, Beijing Union University, Beijing 100191, China
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| Abstract: |
| In order to study the chemical constituents, the ethanol extract of Ainsliaea yunnanensis was isolated and purified by the normal pressure silica column chromatography, Sephadex LH-20, the low pressure cyano chromatography and preparative high pressure liquid chromatography. Ten compounds were isolated and identified as 3β-hydroxystigmast-5-en-7-one(1), 3β-hydroxystigmast-5,22-dien-7-one(2), β-sitosterol(3), stigmasterol(4), β-daucosterol(5), stigmasterol glucoside(6), 3,5-O-dicaffeoylquinic acid(7), 3,5-O-dicaffeoylquinic acid methyl ester(8), caffeic acid(9), protocatechuic acid(10). All compounds are isolated from this plant for the first time, and compounds 2 and 8 are isolated from this genus for the first time. The discovery of the compounds may enrich the chemical constituents of A. yunnanensis and provide a theoretical basis for its rational and effective application. |
| Key words: Ainsliaea yunnanensis, separation and purification, structure identification |
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