| 引用本文: | 朱帮会, 聂雨杉, 黎 雪, 刘春花, 李月婷, 马 雪, 李勇军.有齿鞘柄木根及茎的化学成分研究[J].广西植物,2024,44(12):2291-2300.[点击复制] |
| ZHU Banghui, NIE Yushan, LI Xue, LIU Chunhua,
LI Yueting, MA Xue, LI Yongjun.Chemical constituents of the roots and rhizomata of Torricellia angulata var. intermedia[J].Guihaia,2024,44(12):2291-2300.[点击复制] |
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| 有齿鞘柄木根及茎的化学成分研究 |
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朱帮会1,3, 聂雨杉1,3, 黎 雪1,3, 刘春花1, 李月婷2, 马 雪1, 李勇军1,2,3*
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1. 贵州医科大学 民族药与中药开发应用教育部工程研究中心/省部共建药用植物功效与利用国家重点实验室, 贵阳 550004;2. 贵州医科大学 贵州省药物制剂重点实验室, 贵阳 550004;3. 贵州医科大学 药学院, 贵阳 550025
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| 摘要: |
| 为探究有齿鞘柄木(Torricellia angulata var. intermedia)根及茎的化学成分,该研究采用D101大孔树脂、硅胶、制备型HPLC等色谱方法,对有齿鞘柄木根及茎的45%乙醇提取物进行分离纯化,通过一维质谱、二维质谱、高分辨质谱等鉴定化合物结构,并比较实验与理论计算的电子圆二色谱(electronic circular dichroism,ECD)光谱数据来确定化合物绝对构型。结果表明:从有齿鞘柄木的根及茎中得到15个化合物,分别鉴定为(7S,8S)-8,9-dihydroxy-3,5,7-trimethoxy phenicol-4-O-β-D-glucoside(1)、腺苷(2)、(8E)-decaene-4,6-diyn-1-O-α-L-rhamnopyranosyl-(1→6)-β-D-glucopyranoside(3)、2,6-二甲氧基苯醌(4)、软脂酸(5)、2,2'-氧代双(1,4-二叔丁苯)(6)、syringaldeyde-4-O-β-D-glucopyranoside(7)、植物醇(8)、对羟基苯甲醛(9)、(8R)-deca-2-trans-2-ene-4,6-diyn-1,8-diol(10)、烟酰胺(11)、aralidioside(12)、β-胡萝卜苷(13)、griselinoside(14)、2-(4-hydroxy-3-methoxyphenyl)-3-(2-hydroxy-5-methoxyphenyl)-3-oxo-1-propanol(15)。其中,化合物1为新的化合物,化合物2-4、6、7、9-12、15首次从鞘柄木属中分离得到。该研究结果丰富了有齿鞘柄木药材的植物化学信息,为其药效物质的阐明、质量标志物的寻找、药理机制的探寻及药物的研发提供了物质基础。 |
| 关键词: 鞘柄木属, 有齿鞘柄木, 化学成分, 分离纯化, 结构鉴定 |
| DOI：10.11931/guihaia.gxzw202309003 |
| 分类号:Q946 |
| 文章编号:1000-3142(2024)12-2291-10 |
| 基金项目:国家自然科学基金(U1812403); 贵州省高层次创新型人才培养计划项目(20165677)。
第一作者: 朱帮会(1997—),硕士研究生,研究方向为中药民族药药效物质与质量控制技术,(E-mail)2806831020@qq.com。 |
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| Chemical constituents of the roots and rhizomata of Torricellia angulata var. intermedia |
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ZHU Banghui1,3, NIE Yushan1,3, LI Xue1,3, LIU Chunhua1,
LI Yueting2, MA Xue1 , LI Yongjun1,2,3*
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1. Engineering Research Center for the Development and Application of Ethnic Medicine and TCM(Ministry of Education), State Key
Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550004, China;2. Guizhou
Provincial Key Laboratory of Pharmaceutics, Guizhou Medical University, Guiyang 550004, China;3. School of Pharmacy, Guizhou Medical University, Guiyang 550025, China
1. Engineering Research Center for the Development and Application of Ethnic Medicine and TCM(Ministry of Education)
, State Key
Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550004, China; 2. Guizhou
Provincial Key Laboratory of Pharmaceutics, Guizhou Medical University, Guiyang 550004, China;
3. School of Pharmacy, Guizhou Medical University, Guiyang 550025, China
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| Abstract: |
| Torricellia angulata var. intermedia belongs to the genus Torricellia. In China, this plant is mainly found in Guangxi, Guizhou, Yunnan and Sichuan. T. angulata var. intermedia has been prescribed for the treatment of various diseases in the field of traditional Chinese medicine, such as rheumatoid arthritis, closed soft-tissue injuries. In order to study the chemical constituents of the roots and rhizoma of T. angulata var. intermedia. This paper explored the chemical constituents of 45% ethanol extraction of T. angulata var. intermedia by D101 macroporous resin, silica gel, preparative high performance liquid chromatography and other methods. Their structures were elucidated by extensive spectroscopic analysis such as 1D-NMR, 2D-NMR, HR-ESI-MS and so on. The absolute configurations were determined by comparison of the experimental and theoretically calculated ECD. The results were as follows: Fifteen compounds were isolated and identified as(7S,8S)-8,9-dihydroxy-3,5,7-trimethox phenicol-4-O-β-D-glucoside(1), adenosine(2),(8E)-decaene-4,6-diyn-1-O-α-L-rhamnopyranosyl-(1→6)-β-D-glucopyranoside(3), 2,6-dimethoxy-p-benzoquinone(4), palmiticacid(5), 2,2'-oxybis(1,4-di-tert-butylbenzene)(6), syringaldeyde-4-O-β-D-glucopyranoside(7), phytol(8), p-hydroxybenzaldehyde(9),(8R)-deca-2-trans-2-ene-4,6-diyn-1,8-diol(10), nicotinamide(11), aralidioside(12), β-daucosterol(13), griselinoside(14), 2-(4-hydroxy-3-methoxyphenyl)-3-(2-hydroxy-5-methoxyphenyl)-3-oxo-1-propanol(15). Among them, 1 was a new compound, 2-4, 6, 7, 9-12 and 15 were isolated from Toricellia for the first time. The results of this study enrich the phytochemical information of T. angulata var. intermedia, and provide a material basis for the elucidation of its pharmacodynamic substances, the search for quality markers, the exploration of pharmacological mechanisms and the development of drugs. |
| Key words: Torricellia, Torricellia angulata var. intermedia, chemical constituents, isolation and purification, structure identification |
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