| 引用本文: | 常燕玲, 梁晓琴, 黄 艳, 潘立卫, 侯 萍, 任晨阳, 李 俊.大萼香茶菜中的二萜化学成分研究[J].广西植物,2023,43(11):2113-2119.[点击复制] |
| CHANG Yanling, LIANG Xiaoqin, HUANG Yan, PAN Liwei,
HOU Ping, REN Chenyang, LI Jun.Diterpenoids from the aerial parts of Isodon macrocalyx[J].Guihaia,2023,43(11):2113-2119.[点击复制] |
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| 大萼香茶菜中的二萜化学成分研究 |
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常燕玲, 梁晓琴, 黄 艳, 潘立卫, 侯 萍, 任晨阳, 李 俊*
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广西师范大学 化学与药学学院, 省部共建药用资源化学与药物分子工程国家重点实验室, 广西 桂林 541004
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| 摘要: |
| 为研究大萼香茶菜(Isodon macrocalyx )的化学成分,该文采用硅胶、ODS、Sephadex LH-20、反相C18半制备高效液相等色谱方法对大萼香茶菜地上部分进行分离纯化,并利用1H NMR、13C NMR和HR-ESI-MS等波谱数据,以及结合
参考文献,鉴定了这些化合物的结构。结果表明:从大萼香茶菜地上部分分离得到13个二萜,它们分别是19-羟基陶塔酚(1)、macrophynin E(2)、inumakoic acid(3)、inumakiol D(4)、4β-carboxy-19-nortotarol(5)、(-)-lambertic acid(6)、2-oxo-5-fagonene(7)、isodoterniofiln B(8)、长管贝壳杉素E(9)、长管香茶菜素A(10)、牛尾草素H(11)、16S-dihydrolongikaurin A(12)和ent-3S,16S,17-trihydroxy-kauran-2-one(13)。所有得到的二萜均为首次从该植物中分离得到。 |
| 关键词: 大萼香茶菜, 二萜, 19-羟基陶塔酚, 16S-dihydrolongikaurin A, 牛尾草素H |
| DOI：10.11931/guihaia.gxzw202207002 |
| 分类号:Q946 |
| 文章编号:1000-3142(2023)11-2113-07 |
| 基金项目:国家自然科学基金(32060097); 广西自然科学基金(2018GXNSFDA050007)。 |
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| Diterpenoids from the aerial parts of Isodon macrocalyx |
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CHANG Yanling, LIANG Xiaoqin, HUANG Yan, PAN Liwei,
HOU Ping, REN Chenyang, LI Jun*
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State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and
Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, Guangxi, China
State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and
Pharmaceutical Sciences, Guangxi Normal University, Guilin 541004, Guangxi, China
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| Abstract: |
| To study the constituents of Isodon macrocalyx, thirteen diterpenoids were isolated and purified from the aerial parts of I. macrocalyx by means of various column chromatographic techniques, including silica gel, ODS, Sephadex LH-20 and RP-C18 pre-HPLC. The structures of the isolated diterpenoids were determined on the basis of analyses of spectroscopic methods(1H NMR and 13C NMR spectroscopy), high-resolution electrospray ionization mass spectrometry(HR-ESI-MS), and comparison of their spectroscopic data with previously reported data. The results showed that the diterpenoids were identified as 19-hydroxytotarol(1), macrophynin E(2), inumakoic acid(3), inumakiol D(4), 4β-carboxy-19-nortotarol(5),(-)-lambertic acid(6), 2-oxo-5-fagonene(7), isodoterniofiln B(8), longikaurin E(9), longikaurin A(10), rabdotemin H(11), 16S-dihydrolongikaurin A(12), and ent-3S,16S,17-trihydroxy-kauran-2-one(13). All diterpenoids were isolated from I. macrocalyx for the first time. |
| Key words: Isodon macrocalyx, diterpenoid, 19-hydroxytotarol, 16S-dihydrolongikaurin A, rabdotemin H |
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